This page contains details about the types of research projects we do at Kingston Hospital, including links to the studies themselves.
Interventional trials
An interventional trial is designed to evaluate the direct impacts of treatment or preventative measures on disease. This could be a randomized controlled trial,whereby participants with the same disease will be randomly separated into one of two or more groups: intervention groups or control groups. The objectives of an intervention trial, is to measure the safety and efficacy of whatever drug, device, or other medical intervention is being tested.
Observational studies
An observational study observed certain outcomes are measured, but no attempt is made to affect the outcome. Typically a large population can be studied, over a long period of time, if needed. An observational study could even be a survey in which the investigator is sampling a particular group of people and asking them questions over time.
Registries
A registry study are used to provide information or describe events and patterns, and often to generate hypotheses about a specific patient population to whom study results are meant to apply. Studies can be conducted of people who share common characteristics, with or without the inclusion of comparison groups.
Independent studies
Independent study is a form of educational activity undertaken by an individual student with little to no supervision. A student and their professor will generally agree upon a topic for the student to research with minimal instruction and guidance from the professor for an agreed upon number of academic credits.
Genomic– https://www.nature.com/articles/s41586-020-03065-y
DREAMY – https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.15250
PRISM – https://www.qmul.ac.uk/ccpmg/media/critical-care-and-pmg/documents/PRISM_author_final_version.pdf
https://doi.org/10.1016/j.bjps.2021.05.005
Barea, A., Martinucci, M., Wertheim, D., Morley, I.F.I., Thomson, D. and Soldin, M.G., 2021. Five year basal cell carcinoma recurrence rates treated with curettage and cautery, a single centre retrospective cohort study. Journal of Plastic, Reconstructive & Aesthetic Surgery, 74(8), pp.1931-1971.
https://doi.org/10.1016/j.jaad.2019.06.1302.
Denny, J.W., Barea, A., Wertheim, D., Valiallah, N. and Natkunarajah, J., 2020. Pain management in photodynamic therapy: a retrospective cohort study. Journal of the American Academy of Dermatology, 82(2), pp.483-484.
https://doi.org/10.1016/j.jaci.2020.10.007
This is a muticentre study and includes many more authors not listed in the main text – as part of the PsoProtect study group:
Mahil, S.K., Dand, N., Mason, K.J., Yiu, Z.Z., Tsakok, T., Meynell, F., Coker, B., McAteer, H., Moorhead, L., Mackenzie, T. and Rossi, M.T., 2021. Factors associated with adverse COVID-19 outcomes in patients with psoriasis—insights from a global registry–based study. Journal of Allergy and Clinical Immunology, 147(1), pp.60-71.
https://dx.doi.org/10.36876/smdj.1016
Qureshi, F.U., Krishna, S.K., Sawant, A., Barea, A., Reeken, S. and Natkunarajah, J., 2017. Non-Healing Lesions in a Patient with Chronic Plaque Psoriasis. SM Dermatolog J, 3(2), p.1016.
Recent publication for Saskia Reeken (PI on BADBIR and BSTOP)
https://bdng.org.uk/wp-content/uploads/2017/02/16_2_34.pdf
Reeken, S., 2017. NICE GUIDELINE ON MELANOMA (NG14): A NURSE PERSPECTIVE. Dermatological Nursing, 16(2).
https://doi.org/10.1136/bmj.h3708
Macbeth, F., Newton-Bishop, J., O’Connell, S. and Hawkins, J.E., 2015. Melanoma: summary of NICE guidance. bmj, 351.
Molls, R. 2021. Moving towards a paper-lite Dietetics Department in an Acute Trust (in press).
https://www.journal-of-hepatology.eu/article/S0168-8278(10)60827-6/pdf
Erro, E, Bundy, J, Massie, I, Gander, A, Chalmers, SA, Molls, R, Zhou, M, Sharrat, P, Fuller, B, Hodgson, H, Selden, C. Optimization of the biomass growth for the development of a clinical scale bioartificial liver using a human derived cell line within encapsulated alginate. Journal of Hepatology 2010;52:S322.
https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00342.2005
Molls R, Savransky V, Liu M, Bevans S, Mehta T, Tuder RM, King LS, Rabb H. Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury. Am J Physiol Renal Physiol 2006;290:F1187-F1193.
| Project Short title | Principal Investigator | Main Speciality | Link to the study |
| READY | Ms Justine Sweet | Audiology | The READY Study | The University of Manchester Read more |
| 7Tesla MRI Scanning in AD and FTLD | Jeremy Isaacs | Dementias and Neurodegeneration | Read more |
| RETAKE – Return to Work After Stroke | Dr Asis Kumar | Stroke | Relative/Carer info sheet Participant info sheet |
| Pastoral, spiritual and religious care of children facing end of life | Rev Susan Van Beveran | Health Services Research | Read more |
| REGAIN | Helen Matthews | Infection | REGAIN Trial (warwick.ac.uk) Read more |
| Biologics for Rheumatoid Arthritis Pain (BIORA-PAIN) | Dr Julekha Wajed | Musculoskeletal | Read more |
| OPTIMAL CARE (work packages 2-5) | Dr Laura Nightingale | Health services and delivery research | Read more |
The Government wants to see a dramatic and sustained improvement in the performance of The Government’s Plan for Growth, published in March 2011, with the aim of increasing the number of patients who have the opportunity to participate in research. As part of its research performance reporting to the Department of Health under the ‘Performance in initiating and delivering clinical research initiative’, or PID, the Foundation Trust is required to publish information regarding its performance in setting up and delivering research in a timely manner.
In order to meet the requirements of the Department of Health the Trust has to provide the following information on non-commercial studies:
Information regarding our performance in meeting the 70 day target for the time it takes from receiving a valid research application to the recruitment of our first patient to a trial.
We are also required to publish the following information regarding commercial contract clinical trials:
Information on all commercial clinical trials closed during the last 12 months
Information on our performance in recruiting the target number of patients to a trial within the target time.
This information is expected to be publicly available and the performance of the Trust against the National Institute for Health Research benchmarks will be published along with similar information from other organisations.
You can access the performance tables for Kingston Hospital NHS Foundation Trust by clicking on the link below:
Please note that the information published in these documents represents only the clinical trials meeting the criteria set down by the Department of Health. There are many other research studies running in the Trust which are not published here. If you want further information on the wide range of studies we are running please contact the R&I Department
CTP Submission Platform – Public Trust View (Version 1.0.3) (nihr.ac.uk)
Integrated Research Application System – https://www.myresearchproject.org.uk/
Planning your application for HRA Approval – HRA Approval – Health Research Authority
Clinical trials for medicines: apply for authorisation in the UK – Clinical trials for medicines: apply for authorisation in the UK – GOV.UK (www.gov.uk)
